The Molecules of HIV

Note: this site last updated in 2006

Beta2-microglobulin

An article from "The Molecules of HIV" (c) Dan Stowell
www.mcld.co.uk/hiv

Beta-2-microglobulin is a plasma protein shed from activated lymphocytes">lymphocytes. The levels of beta-2-microglobulin in blood serum increase with progressive HIV infection, and have been found to be high in patients with AIDS Dementia Complex. This makes the beta-2-microglobulin assay another possible test to indicate HIV progression.

As the name suggests, beta-2-microglobulin is a small and globular (i.e. roughly spherical) protein. It is found on the surface of most nucleated cells, and associates with class I MHC molecules on the cell surface.

Beta-2-microglobulin was first identified in the 1960s. The following scientific paper, from 1968, is one of the first to describe the protein:

www.jbc.org/cgi/content/abstract/243/15/4095

Written by
Dan Stowell
(©2002-2006)

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